Dr. Ryoko Ihara is the Chief Physician, Neurology, at the Tokyo Metropolitan Institute for Geriatrics and Gerontology. She has been involved in nationwide clinical studies such as J-ADNI and J-TRC and global clinical trials, and is playing an important role in global harmonization. She also supervises clinical practice with anti-amyloid therapy, and her institution is one of the leading hospitals for this therapy in Japan.