Rising longevity and the aging of boomers worldwide are radically altering both the demographic landscape and every aspect of our personal, social, financial, and political lives. What gero-science breakthroughs are currently at the tipping point? How can we ensure that our health spans and brain spans match our life spans? And how can we secure abundant brain health for all, not just the wealthy? Why and how must we stop Alzheimer’s from being the sinkhole of the 21st century—and do it now!